Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials.
Identifieur interne : 001D81 ( Main/Exploration ); précédent : 001D80; suivant : 001D82Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials.
Auteurs : Sanne A E. Peters [Pays-Bas] ; Michiel L. Bots [Pays-Bas] ; Bernard Canaud [France] ; Andrew Davenport [Royaume-Uni] ; Muriel P C. Grooteman [Pays-Bas] ; Fatih Kircelli [Turquie] ; Francesco Locatelli [Italie] ; Francisco Maduell [Espagne] ; Marion Morena [France] ; Menso J. Nubé [Pays-Bas] ; Ercan Ok [Turquie] ; Ferran Torres [Espagne] ; Mark Woodward [États-Unis] ; Peter J. Blankestijn [Pays-Bas]Source :
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [ 1460-2385 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Cause de décès (tendances), Dialyse rénale (), Défaillance rénale chronique (), Défaillance rénale chronique (mortalité), Europe (épidémiologie), Facteurs de risque, Femelle, Humains, Hémodiafiltration (), Modèles de hasards proportionnels, Mâle, Sujet âgé, Taux de survie (tendances).
- MESH :
- mortalité : Défaillance rénale chronique.
- tendances : Cause de décès, Taux de survie.
- épidémiologie : Europe.
- Adulte d'âge moyen, Dialyse rénale, Défaillance rénale chronique, Facteurs de risque, Femelle, Humains, Hémodiafiltration, Modèles de hasards proportionnels, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Europe.
- methods : Hemodiafiltration, Renal Dialysis.
- mortality : Kidney Failure, Chronic.
- therapy : Kidney Failure, Chronic.
- trends : Cause of Death, Survival Rate.
- Aged, Female, Humans, Male, Middle Aged, Proportional Hazards Models, Risk Factors.
Abstract
Mortality rates remain high for haemodialysis (HD) patients and simply increasing the HD dose to remove more small solutes does not improve survival. Online haemodiafiltration (HDF) provides additional clearance of larger toxins compared with standard HD. Randomized controlled trials (RCTs) comparing HDF with conventional HD on all-cause and cause-specific mortality in end-stage kidney disease (ESKD) patients reported inconsistent results and were at high risk of bias. We conducted a pooled individual participant data analysis of RCTs to provide the most reliable evidence to date on the effects of HDF on mortality outcomes in ESKD patients.
DOI: 10.1093/ndt/gfv349
PubMed: 26492924
Affiliations:
- Espagne, France, Italie, Pays-Bas, Royaume-Uni, Turquie, États-Unis
- Angleterre, Catalogne, Grand Londres, Hollande-Septentrionale, Languedoc-Roussillon, Maryland, Occitanie (région administrative), Utrecht (province)
- Amsterdam, Barcelone, Londres, Montpellier, Oxford, Utrecht
- University College de Londres, Université autonome de Barcelone, Université d'Oxford
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Le document en format XML
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Nubé</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nephrology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ok, Ercan" sort="Ok, Ercan" uniqKey="Ok E" first="Ercan" last="Ok">Ercan Ok</name><affiliation wicri:level="1"><nlm:affiliation>Division of Nephrology, Ege University School of Medicine, Izmir, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Division of Nephrology, Ege University School of Medicine, Izmir</wicri:regionArea><wicri:noRegion>Izmir</wicri:noRegion></affiliation></author><author><name sortKey="Torres, Ferran" sort="Torres, Ferran" uniqKey="Torres F" first="Ferran" last="Torres">Ferran Torres</name><affiliation wicri:level="4"><nlm:affiliation>Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain Biostatistics and Data Management Platform, IDIBAPS, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain Biostatistics and Data Management Platform, IDIBAPS, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, UK The George Institute for Global Health, University of Sydney, Sydney, Australia Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, UK The George Institute for Global Health, University of Sydney, Sydney, Australia Department of Epidemiology, Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Blankestijn, Peter J" sort="Blankestijn, Peter J" uniqKey="Blankestijn P" first="Peter J" last="Blankestijn">Peter J. 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Peters</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, UK Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, UK Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L" last="Bots">Michiel L. Bots</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Canaud, Bernard" sort="Canaud, Bernard" uniqKey="Canaud B" first="Bernard" last="Canaud">Bernard Canaud</name><affiliation wicri:level="3"><nlm:affiliation>Nephrology, Dialysis and Intensive Care Unit, CHRU, Montpellier, France Dialysis Research and Training Institute, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nephrology, Dialysis and Intensive Care Unit, CHRU, Montpellier, France Dialysis Research and Training Institute, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Davenport, Andrew" sort="Davenport, Andrew" uniqKey="Davenport A" first="Andrew" last="Davenport">Andrew Davenport</name><affiliation wicri:level="4"><nlm:affiliation>University College London, Centre for Nephrology, Royal Free Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, Centre for Nephrology, Royal Free Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Grooteman, Muriel P C" sort="Grooteman, Muriel P C" uniqKey="Grooteman M" first="Muriel P C" last="Grooteman">Muriel P C. Grooteman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nephrology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kircelli, Fatih" sort="Kircelli, Fatih" uniqKey="Kircelli F" first="Fatih" last="Kircelli">Fatih Kircelli</name><affiliation wicri:level="1"><nlm:affiliation>Division of Nephrology, Ege University School of Medicine, Izmir, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Division of Nephrology, Ege University School of Medicine, Izmir</wicri:regionArea><wicri:noRegion>Izmir</wicri:noRegion></affiliation></author><author><name sortKey="Locatelli, Francesco" sort="Locatelli, Francesco" uniqKey="Locatelli F" first="Francesco" last="Locatelli">Francesco Locatelli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Alessandro Manzoni Hospital, Lecco, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Nephrology, Alessandro Manzoni Hospital, Lecco</wicri:regionArea><wicri:noRegion>Lecco</wicri:noRegion></affiliation></author><author><name sortKey="Maduell, Francisco" sort="Maduell, Francisco" uniqKey="Maduell F" first="Francisco" last="Maduell">Francisco Maduell</name><affiliation wicri:level="3"><nlm:affiliation>Nephrology Department, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Nephrology Department, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Morena, Marion" sort="Morena, Marion" uniqKey="Morena M" first="Marion" last="Morena">Marion Morena</name><affiliation wicri:level="3"><nlm:affiliation>Dialysis Research and Training Institute, Montpellier, France Biochemistry Laboratory, CHRU, Montpellier, France U1046 INSERM, University of Montpellier I, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Dialysis Research and Training Institute, Montpellier, France Biochemistry Laboratory, CHRU, Montpellier, France U1046 INSERM, University of Montpellier I, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Nube, Menso J" sort="Nube, Menso J" uniqKey="Nube M" first="Menso J" last="Nubé">Menso J. Nubé</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nephrology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ok, Ercan" sort="Ok, Ercan" uniqKey="Ok E" first="Ercan" last="Ok">Ercan Ok</name><affiliation wicri:level="1"><nlm:affiliation>Division of Nephrology, Ege University School of Medicine, Izmir, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Division of Nephrology, Ege University School of Medicine, Izmir</wicri:regionArea><wicri:noRegion>Izmir</wicri:noRegion></affiliation></author><author><name sortKey="Torres, Ferran" sort="Torres, Ferran" uniqKey="Torres F" first="Ferran" last="Torres">Ferran Torres</name><affiliation wicri:level="4"><nlm:affiliation>Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain Biostatistics and Data Management Platform, IDIBAPS, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain Biostatistics and Data Management Platform, IDIBAPS, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, UK The George Institute for Global Health, University of Sydney, Sydney, Australia Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, UK The George Institute for Global Health, University of Sydney, Sydney, Australia Department of Epidemiology, Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Blankestijn, Peter J" sort="Blankestijn, Peter J" uniqKey="Blankestijn P" first="Peter J" last="Blankestijn">Peter J. Blankestijn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author></analytic><series><title level="j">Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association</title><idno type="eISSN">1460-2385</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cause of Death (trends)</term><term>Europe (epidemiology)</term><term>Female</term><term>Hemodiafiltration (methods)</term><term>Humans</term><term>Kidney Failure, Chronic (mortality)</term><term>Kidney Failure, Chronic (therapy)</term><term>Male</term><term>Middle Aged</term><term>Proportional Hazards Models</term><term>Renal Dialysis (methods)</term><term>Risk Factors</term><term>Survival Rate (trends)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Cause de décès (tendances)</term><term>Dialyse rénale ()</term><term>Défaillance rénale chronique ()</term><term>Défaillance rénale chronique (mortalité)</term><term>Europe (épidémiologie)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Hémodiafiltration ()</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Sujet âgé</term><term>Taux de survie (tendances)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hemodiafiltration</term><term>Renal Dialysis</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Défaillance rénale chronique</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Cause de décès</term><term>Taux de survie</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Cause of Death</term><term>Survival Rate</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Europe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Proportional Hazards Models</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Dialyse rénale</term><term>Défaillance rénale chronique</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Hémodiafiltration</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mortality rates remain high for haemodialysis (HD) patients and simply increasing the HD dose to remove more small solutes does not improve survival. Online haemodiafiltration (HDF) provides additional clearance of larger toxins compared with standard HD. Randomized controlled trials (RCTs) comparing HDF with conventional HD on all-cause and cause-specific mortality in end-stage kidney disease (ESKD) patients reported inconsistent results and were at high risk of bias. We conducted a pooled individual participant data analysis of RCTs to provide the most reliable evidence to date on the effects of HDF on mortality outcomes in ESKD patients.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Turquie</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Languedoc-Roussillon</li><li>Maryland</li><li>Occitanie (région administrative)</li><li>Utrecht (province)</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Londres</li><li>Montpellier</li><li>Oxford</li><li>Utrecht</li></settlement><orgName><li>University College de Londres</li><li>Université autonome de Barcelone</li><li>Université d'Oxford</li></orgName></list><tree><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Peters, Sanne A E" sort="Peters, Sanne A E" uniqKey="Peters S" first="Sanne A E" last="Peters">Sanne A E. Peters</name></region><name sortKey="Blankestijn, Peter J" sort="Blankestijn, Peter J" uniqKey="Blankestijn P" first="Peter J" last="Blankestijn">Peter J. Blankestijn</name><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L" last="Bots">Michiel L. Bots</name><name sortKey="Grooteman, Muriel P C" sort="Grooteman, Muriel P C" uniqKey="Grooteman M" first="Muriel P C" last="Grooteman">Muriel P C. Grooteman</name><name sortKey="Nube, Menso J" sort="Nube, Menso J" uniqKey="Nube M" first="Menso J" last="Nubé">Menso J. Nubé</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Canaud, Bernard" sort="Canaud, Bernard" uniqKey="Canaud B" first="Bernard" last="Canaud">Bernard Canaud</name></region><name sortKey="Morena, Marion" sort="Morena, Marion" uniqKey="Morena M" first="Marion" last="Morena">Marion Morena</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Davenport, Andrew" sort="Davenport, Andrew" uniqKey="Davenport A" first="Andrew" last="Davenport">Andrew Davenport</name></region></country><country name="Turquie"><noRegion><name sortKey="Kircelli, Fatih" sort="Kircelli, Fatih" uniqKey="Kircelli F" first="Fatih" last="Kircelli">Fatih Kircelli</name></noRegion><name sortKey="Ok, Ercan" sort="Ok, Ercan" uniqKey="Ok E" first="Ercan" last="Ok">Ercan Ok</name></country><country name="Italie"><noRegion><name sortKey="Locatelli, Francesco" sort="Locatelli, Francesco" uniqKey="Locatelli F" first="Francesco" last="Locatelli">Francesco Locatelli</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Maduell, Francisco" sort="Maduell, Francisco" uniqKey="Maduell F" first="Francisco" last="Maduell">Francisco Maduell</name></region><name sortKey="Torres, Ferran" sort="Torres, Ferran" uniqKey="Torres F" first="Ferran" last="Torres">Ferran Torres</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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